Swyer syndrome, also known as Complete Gonadal Dysgenesis, is a sex development condition which affects individuals with a 46,XY karyotype. Because there is no testicular tissue to produce anti-Muller
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ian hormone and testosterone, individuals with Swyer develop female reproductive structures.
If you want to help improve medical research and psychological support for individuals with these conditions, you can donate to DSDFamilies (https://dsdfamilies.org/donate).
Biology of DSDs playlist:
https://www.youtube.com/playlist?list=PLC2TfoWi4QceBlcKOrFQnTECCOVwrRFzN
Transcripts, sources, and membership at:
https://www.theparadoxinstitute.com/pi.html
References and additional reading:
[1] NIH. (2020). Swyer syndrome. Genetics Home Reference, National Library of Medicine.
[2] Jones, R., Lopez, K. (2014). Chapter 5: Sexual differentiation. Human Reproductive Biology, 4th edition. Elsevier. 95.
[3] LOCAH. (2018). The intersex masterpost. Medium.
[4] NIH. (2020). Swyer syndrome. Genetic and Rare Diseases Information Center.
[5] Azidah, AK. (2013). Swyer syndrome in a woman with 46,XY gonadal dysgenesis. Malaysian Family Physician, 8(2).
[6] Bagci, G., et al. (2011). Complete gonadal dysgenesis 46,XY (Swyer syndrome) in two sisters. Amer Soc Repro Med.
[7] Michala, L., et al. (2008). Swyer syndrome, presentation and outcomes. Journal of Obstetrics and Gynecology, 115(6).
[8] Nollman, J. (2013). An intersex story from X to Y. AIS DSD Support Group.
[9] Taneja, J., et al. (2016). Rare successful pregnancy in a patient with Swyer Syndrome.
